Normal PSA Density Range

PSA Density Threshold:

\[ \text{PSAD} < 0.15 \, \text{ng/mL/cm}^3 \]

PSA Density:

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1. What is PSA Density?

Definition: PSA Density (PSAD) is a calculated value that relates prostate-specific antigen (PSA) levels to prostate volume.

Purpose: It helps distinguish between benign prostate conditions and potential prostate cancer when PSA levels are elevated.

2. How is PSAD Calculated?

The formula for PSA Density is:

\[ \text{PSAD} = \frac{\text{PSA}}{\text{Prostate Volume}} \]

Where:

PSAD — PSA Density (ng/mL/cm³)
PSA — Prostate-Specific Antigen level (ng/mL)
Prostate Volume — Measured by ultrasound or MRI (cm³)

Normal Range: Typically considered normal when < 0.15 ng/mL/cm³

3. Importance of PSAD

Clinical Significance: PSAD helps:

Improve specificity of PSA testing
Guide decisions about prostate biopsy
Monitor patients on active surveillance

4. Using This Calculator

Instructions: Enter your PSA level (ng/mL) and prostate volume (cm³) to calculate your PSA Density.

5. Frequently Asked Questions (FAQ)

Q1: What does an elevated PSAD indicate?
A: While not diagnostic, elevated PSAD (>0.15) may suggest higher likelihood of prostate cancer and often warrants further evaluation.

Q2: How is prostate volume measured?
A: Typically via transrectal ultrasound (TRUS) or MRI, using the ellipsoid formula (length × width × height × π/6).

Q3: Are there different thresholds for different ages?
A: Some studies suggest age-adjusted thresholds, but 0.15 ng/mL/cm³ is the most widely accepted cutoff.

Q4: What if my PSAD is borderline (e.g., 0.14-0.16)?
A: Borderline results should be interpreted in clinical context with other factors like digital exam, family history, and PSA velocity.

Q5: Does PSAD replace PSA testing?
A: No, PSAD is an adjunct to PSA testing that provides additional information when PSA is elevated.